The Effect of oral L-carnitine supplementation on sleep quality in hemodialysis patients Imam Khomeini Hospital in Shirvan in 2013

Hatami, Maryam (2014) The Effect of oral L-carnitine supplementation on sleep quality in hemodialysis patients Imam Khomeini Hospital in Shirvan in 2013. Masters thesis, Sabzevar University of Medical Sciences.

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Abstract

Background and Aim: Poor sleep quality is common among hemodialysis patients. On the other hand, hemodialysis patients are encountered with carnitine deficiency. L-carnitine a dietary supplement that has various metabolic functions, and it decreases the complications during dialysis. The purpose of this study was to determine the effect of oral L-carnitine supplementation on sleep quality in hemodialysis patients. Materials and Methods: In this double blind randomized clinical trial, 59 qualified hemodialysis patients were gone under investigation in Imam Khomeini Hospital in Shirvan during 2013. Patients were divided into intervention and control groups by permutation blocking method. Patients in the intervention group received 500 mg of L-carnitine supplement twice a day and the placebo group were similarly taking placebo for 12 weeks. Tools for data collection consist of; demographic form and Pittsburgh Sleep Quality Index that before and after the intervention was completed. Data with SPSS statistical software version 11.5 and using independent t-test, Mann-Whitney test, chi-square, Fisher tests, Wilcoxon Analysis of Covariance and with confidencs level  95 were analyzed. Results: Analysis of the data showed that sleep quality score between the two groups before the intervention was not statistically significant. The mean PSQI score, after the intervention was 6.4±2.8 in the drug group and 9.7±3.48 in the placebo group, that in both groups showed significant differences compared to baseline(P0.05). Based on the Pittsburgh Sleep Quality Index, the lower score demonstrates a better condition of sleep qualiy. Of course, The PSQI score decreased by 33% in the intervention group and by 3.9% in the control group and statistical analysis showed significant differences between the two groups(P0.05). Conclusion: This study showed that oral L-carnitine supplementation can improve sleep quality in hemodialysis patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Hemodialysis, L-carnitine, sleep quality
Subjects: R Medicine > RT Nursing
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Saeed Shoja
Date Deposited: 12 May 2018 05:45
Last Modified: 20 Jan 2019 09:55
URI: http://eprints.medsab.ac.ir/id/eprint/369

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