Beneficial Effects of Rosmarinus Officinalis Leaves Extract on Memory Deficit of 6-Hydroxydopamine Lesioned Rats

Tamadoni, Mahdieh and Haji Ghasem Kashani, Maryam and Abrari, Kataneh (2017) Beneficial Effects of Rosmarinus Officinalis Leaves Extract on Memory Deficit of 6-Hydroxydopamine Lesioned Rats. Journal of Biomedicine and Health, 2 (1). pp. 9-23.

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Official URL: http://www.jbiom.com/article_53797.html

Abstract

 Background and Aims: Loss of dopamine in the hippocampus, causes memory deficiency in Parkinson�s disease. Rosemary leaves extract (RE) has protective effects on neurons. It was evaluated whether RE restore defective memory of 6-OHDA injured rats. Methods: Male Wistar rats were injected by bilateral intra-nigral of 6-OHDA (6μg) and divided into three treated and one lesioned group which were orally given RE (25, 50 and 100 mg/kg) once daily for 28 days and distilled water respectively. Fifth group as control received bilateral intra-nigral saline instead of neurotoxin. The escape latency, traveled distance and swimming speed parameters were measured 24h after the last training session (probe) and analyzed by two-way repeated measures ANOVA. BrdU-positive cells in the CA1, CA3 and dentate gyrus regions of the hippocampus were counted. Results: Lesioned rats showed significant increase of escape latency and decrease of swimming time in the original platform quadrant, as compared with control group. RE at all doses, significantly decreased the escape latency (P<0.05) compared to lesioned group. There was a significant increase of swimming time in the original platform of 50, and 100mg/kg- treated groups as compared to lesioned rats. Conclusion: RE improved spatial memory retention at doses of 50 and 100mg/kg and may serve as candidate for herbal therapeutic to improve spatial memory of PD. BrdU-positive cells of the CA1, CA3 and dentate gyrus increased significantly in the RE-100 treated group, as compared with the lesion group. Hippocampus was protected against neurodegenerative effects induced by 6-OHDA in the presence of RE

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Saeed Shoja
Date Deposited: 18 Feb 2018 09:30
Last Modified: 18 Feb 2018 09:30
URI: http://eprints.medsab.ac.ir/id/eprint/41

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