Rezaei-Seresht, Esmail and Mireskandari, Erfan and Kheirabadi, Mitra and Cheshomi, Hamid and Rezaei-Seresht, Hasan and Aldaghi, Leila Sadat (2017) Synthesis and anticancer activity of new azo compounds containing extended π-conjugated systems. Chemical Papers, 71 (8). pp. 1463-1469.
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Abstract
Abstract: A series of novel azo compounds with extended π-conjugated systems were prepared by azo coupling reaction compounds trans-2-(4′-aminostyryl)-thiophene, 1-(4-aminophenyl)-4-phenyl-1,3-butadiene and 4-amino-4′-methoxystilbene with some phenols. The compounds were evaluated for their cytotoxicity against breast cancer adenocarcinoma (MCF-7), cervix adenocarcinoma (HeLa) and human embryonic kidney (HEK 293) cell lines using the MTT assay. The results showed all derivatives had more toxic effects than tamoxifen. Of all the compounds tested, the azo product obtained from coupling trans-2-(4′-Aminostyryl)-thiophene with 2-naphthol (compound 5b) exhibited the potent in vitro antiproliferative activity with IC50 27 ± 1 and 18 ± 0 µg/mL against MCF-7 and HeLa cell lines, respectively, while it was devoid of any cytotoxicity against normal HEK 293 cells even at 200 µg/mL.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Saeed Shoja |
| Date Deposited: | 27 Feb 2018 04:43 |
| Last Modified: | 27 Feb 2018 04:43 |
| URI: | http://eprints.medsab.ac.ir/id/eprint/230 |
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