[HTML][HTML] Ectopic Expression of Human DPPA2 Gene in ESCC Cell Line Using Retroviral System
M Khaleghizadeh, MM Forghanifard… - Avicenna journal of …, 2018 - ncbi.nlm.nih.gov
Background: Cancer/Testis Antigens (CTAs) are a sub-group of tumor-associated antigens
which are expressed normally in germ line cells and trophoblast, and aberrantly in a variety
of malignancies. One of the most important CTAs is Developmental Pluripotency Associated-
2 (DPPA2) with unknown biological function. Considering the importance of DPPA2 in
developmental events and cancer, preparing a suitable platform to analyze DPPA2 roles in
the cells seems to be necessary. Methods: In this study, the coding sequence of DPPA2 …
which are expressed normally in germ line cells and trophoblast, and aberrantly in a variety
of malignancies. One of the most important CTAs is Developmental Pluripotency Associated-
2 (DPPA2) with unknown biological function. Considering the importance of DPPA2 in
developmental events and cancer, preparing a suitable platform to analyze DPPA2 roles in
the cells seems to be necessary. Methods: In this study, the coding sequence of DPPA2 …
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