Askari, Asra and Rashidlamir, Amir and Bijeh, Nahid and momeni-moghaddam, Majid (2018) Changes in Plasma Levels and Expression of Neurotrophin-3 Gene in Multiple Sclerosis Patients Following 8-Weeks Aquatic and Resistance Exercise Training. Journal of Sabzevar University of Medical Sciences, 25 (3). pp. 451-460.
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Abstract
Background:Neurotrophin-3 is among the biomarkers studied in MS.Regarding the fact that Exercise training has been proposed as an effective non-drug way of treating Multiple Sclerosis(MS),the present study aims at investigatingthe effect of eight weeks� aquatic exercise and resistance training programs on the plasmatic levels and gene expression of neurotrophin-3in MS patients.Materials and methods:To the aims of the present study,30women with MS were randomly selected and assigned to three groups:the control group,resistance training group,and aquatic exercise group. Resistance training and aquatic exercise programs were used for 8weeks.After separating plasma and PBMNcells,plasmatic levels and the expression of neurotrophin-3gene were measured via ELISA and real-timePCR,respectively.Inorder to compare the means,plasmatic levels and the gene expression of neurotrophin-3of the three groups were Analyzed by the ANCOVAtest at the significance level of p�0.05through SPSS18. Results:The results showed a significant increase in plasma levels neurotrophin-3of the three groups (p=0.001).The Scheffe post hoc test was significant in two by two comparisons of the aquatic group and resistance training group with the control group (p=0.001,p=0.001,respectively).However,the difference between the aquatic and resistance groups was not significant(p=0.329).Moreover,there was a significant increase in the gene expression of neurotrophin-3of the three groups(p=0.001).Based on the Scheffe test,the mean differences between the aquatic and resistance groups,and the control group were(p=0.053,p=0.001,respectively).However,non-significant differences in the gene expression of neurotrophin-3were shown between the aquatic group and the resistance group(p=0.08).Conclusion:The findings of the present study indicated that both the resistance training and the aquatic exercise can increase plasmatic levels and the gene expression of neurotrophin-3in MS patients.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Saeed Shoja |
| Date Deposited: | 15 Sep 2018 04:33 |
| Last Modified: | 15 Sep 2018 04:33 |
| URI: | http://eprints.medsab.ac.ir/id/eprint/711 |
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