Faridi, Sonia and Zeinal zadeh, Narges (2018) RAD51 135G>C polymorphism and breast cancer risk in Northwest of Iran. Journal of Sabzevar University of Medical Sciences, 25 (2). pp. 259-269.
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Abstract
Background and objective: Breast cancer is one of the main causes of death among Iranian women. Human RAD51 protein, play a central role in homologous recombination repair of double-stranded DNA breaks and is essential for maintaining genomic stability. A single nucleotide polymorphism in the 5�-untranslated region of RAD51 gene (RAD51 135G�C) is reported to modulate breast cancer risk. The aim of this study was to find out the relationship of this SNP with breast cancer risk among Iranian Azeri Turkish women.Materials and methods: This case-control study was performed on 127 breast cancer cases and 125 controls. Genomic DNA was extracted and the RAD51 135G > C genotype was determined using a PCR�Restriction Fragment Length Polymorphism (RFLP) based assay and confirmed by sequencing. The results were analyzed statistically. Results: The frequencies of CC, CG and GG genotypes of RAD51 135G�C were 1.613, 20.161 and 78.225 in control group and 2.362, 24.409 and 73.228 in patients, respectively. The results showed no significant differences among patients and controls groups.Conclusion: The data presented here may suggest that the RAD51 135G > C polymorphism is not associated with breast cancer risk in Iranian Azeri population.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Saeed Shoja |
| Date Deposited: | 11 Sep 2018 05:06 |
| Last Modified: | 11 Sep 2018 05:06 |
| URI: | http://eprints.medsab.ac.ir/id/eprint/690 |
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