Setorki, Mahboubeh and Mahmoodi, Razieh and Zanganeh nezhad, Zahra (2018) Effect of Biarum carduchrum in 6-hydroxydopamine-induced Parkinsonism in rats: using behavioral tests. Journal of Sabzevar University of Medical Sciences, 25 (2). pp. 293-301.
|
Text
JSUMS_Volume 25_Issue 2_Pages 293-301.pdf Download (833kB) | Preview |
Abstract
Introduction: Parkinson's disease results from degenerative loss of dopaminergic neurons in the substantia nigra and other part of the brain stem. Oxidative stress plays a major role in neuronal death in this disease. The aim of this study is to evaluate the effect of Biarum carduchrum extract in treatment of Parkinson's disease.Methods: Rats were divided randomly into 5 groups of 8 animals. The control group did not receive any lesion. In Parkinson's group, Parkinson was induced by injection of 6- OHDA in the right anterior mid-brain (MFB). Third, fourth and fifth groups received Biarum carduchrum extract at doses of 100, 200 and 400 mg/kg via gavage for 14 days, 7 days after induction of Parkinson models. On day 15 behavioral tests, including catalepsy and open field was performed. Results: Parkinsonian group showed higher immobility time than control group in catalepsy test and rats treatment with Biarum carduchrum extract at doses of 200 and 400 dramatically reduce the immobilization time.Discussion: The results of this study show that Biarum carduchrum extract can improve motor impairment induced by Parkinson's, although didn�t significantly affect knowledge and anxiety in rats.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Saeed Shoja |
| Date Deposited: | 10 Sep 2018 06:34 |
| Last Modified: | 10 Sep 2018 06:34 |
| URI: | http://eprints.medsab.ac.ir/id/eprint/683 |
Actions (login required)
 |
View Item |
