Investigating the effects of co-treatment of type one interferons and granulocyte colony-stimulating factor on Glucose, triglycerides and cholesterol of blood serum in Syrian mouse

Lari, Roya and Mahdavi Shahri, Naser and Moghimi, Ali and Rojhan Nezhad, Mehrnegar and Izi, Leila (2018) Investigating the effects of co-treatment of type one interferons and granulocyte colony-stimulating factor on Glucose, triglycerides and cholesterol of blood serum in Syrian mouse. Journal of Sabzevar University of Medical Sciences, 25 (1). pp. 93-100.

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Abstract

Background and purpose: granulocyte colony-stimulating factor (G-CSF) has a major role in blood cells differentiation especially in neutrophils, therefore G-CSF widely has been used in treatment of chemotherapy-induced neutropenia. Different lines of evidence indicated that G-CSF is increased in inflammatory situation and has inflammatory characteristics. Unlike G-CSF, type I interferones (IFNs) have been shown to have anti-inflammatory effects. The aim of this study was to investigate whether type I IFNs can normalize the effects of G-CSF on blood factors. Materials and methods: forty-two mice (male, eight weeks) were divided into six groups of seven, which includes Group 1 (control) injection of distilled water, Group 2 injection 200 µg/kg b.w. G-CSF, Group 3 injection 200 µg/kg b.w. Alfa interferon (IFN-α), Group 4 injection 200 µg/kg b.w. interferon beta (IFN-β), Group 5 injection 200 µg/kg b.w. G-CSF+200 µg/kg b.w. IFN-α, Group 6 injection 200 µg/kg b.w. G-CSF+200 µg/kg b.w. IFN-β. After 28 days, blood was taken from each mouse heart and blood biochemical parameters (Glucose, Triglyceride, Cholestrol) was investigated. Results: surprisingly, in most cases, the G-CSF and type one IFNs alone or simultaneously reduced the levels of Glucose, triglycerides and cholesterol. Also the reduction of glucose, triglycerides and cholesterol were higher in G-CSF and INFs in compare with G-CSF alone. Our data raise the possibility that, G-CSF and INF-α/β have some similarity in signaling pathway which has to be investigated.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Depositing User:	Saeed Shoja
Date Deposited:	24 Jun 2018 08:42
Last Modified:	24 Jun 2018 08:42
URI:	http://eprints.medsab.ac.ir/id/eprint/469

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