Liamani, Ouafia and Moulessehoul, Soraya and Benzeguir, Ismat (2017) Study of aneuploidies in gametes of infertile males by using FISH technique. Journal of Biomedicine and Health, 2 (1). pp. 32-38.
Full text not available from this repository.Abstract
Male factors leading to infertility account for at least half of all cases of infertility worldwide. In this study, we used multicolor fluorescent in situ hybridization (FISH) probes for chromosomes 13, 18, 21, X and Y to evaluate the aneuploidy incidence in sperm cells. The study group included 12 males with infertility and oligoasthenoteratozoospermia (OAT). FISH revealed a significantly higher incidence of sperm aneuploidies compared with controls. By comparing the incidence of the disomy in the OAT group, the highest incidence was the sex chromosome disomy, followed by the disomy of the chromosomes 13, 21 and 18, respectively. The nulisomy incidence in the OAT group was higher for the sex chromosomes, followed by the nulisomy of the autosomes 13, and then 21 and 18. In conclusion, FISH may be considered as an additional assay for the evaluation of spermatozoa in addition to standard analysis, thus playing an important role during proper diagnosis and treatment of infertility. Since currently intracytoplasmic sperm injection (ICSI) is frequently used for patients with OAT, it is important to inform patients if they might have an increased risk of aneuploidies in embryos.Â
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Saeed Shoja |
| Date Deposited: | 18 Feb 2018 09:31 |
| Last Modified: | 18 Feb 2018 09:31 |
| URI: | http://eprints.medsab.ac.ir/id/eprint/43 |
Actions (login required)
 |
View Item |
