Ferula gummosa is widely used in traditional medicine to treat a variety of ailments. This work evaluated the safety of F. gummosa root in pregnancy, lactation, and juvenile periods. This study was performed in three parts: (1) pregnant rats were received diet containing 0 (control), 150 , or 700 mg/kg of F. gummosa root during pregnancy; (2) Lactating rats were treated with diet containing the root (0, 150, or 700 mg/kg) during lactation period; (3) juvenile rats were received 4 weeks diet containing the root (0, 150, or 700 mg/kg). F. gummosa at both doses had no significant effects on the duration of pregnancy, maternal weight, and the number of delivered pups, but at dose of 700 mg/kg decreased birthweight of the pups. In lactation period, F. gummosa had no significant effects on mortality, body weight, body length, the weight of organs, and blood biochemical parameters of offspring. In juvenile rats, food consumption, body weight, and WBCs number were decreased in treated groups. No histopathological lesions were detected in the brain, heart, liver, lungs and kidney of offspring, and juvenile rats in treated groups. LC/MS/MS analysis confirmed systemic absorption of active constituents of the root by the oral route of administration. In conclusion, F. gummosa root did not produce significant toxic effects during pregnancy, lactation, and juvenile period. But, decrease in birthweight of delivered pups and in weight gain of juvenile rats should be considered in the long-term consumption of this plant.
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Research Article
Toxicity assessment of Ferula gummosa administration during pregnancy, lactation, and juvenile period in rat
Mohammad Mahdi Vahedi Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; ; Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; View further author information, Davood Mahdian Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information, Amir Hossein Jafarian Cancer Molecular Pathology Research Center, Ghaem Hospital Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information, Mehrdad Iranshahi Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information, Mahdi Esmaeilizadeh Department of Basic Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran; View further author information & Ahmad Ghorbani Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, IranCorrespondenceghorbania@mums.ac.ir
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Mohammad Mahdi Vahedi Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; ; Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;
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, Davood Mahdian Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information
, Amir Hossein Jafarian Cancer Molecular Pathology Research Center, Ghaem Hospital Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information
, Mehrdad Iranshahi Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information
, Mahdi Esmaeilizadeh Department of Basic Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran; View further author information
& Ahmad Ghorbani Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, IranCorrespondenceghorbania@mums.ac.irView further author information
Pages 199-205
Received 27 Jun 2016
Accepted 28 May 2017
Published online: 05 Jul 2017
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