Toenail mineral concentration and risk of esophageal squamous cell carcinoma, results from the Golestan Cohort Study

Hashemian, Maryam and Murphy, Gwen and Etemadi, Arash and Poustchi, Hossein and Brockman, John D. and Kamangar, Farin and Pourshams, Akram and Khoshnia, Masoud and Gharavi, Abdolsamad and Dawsey, Sanford M. and Brennan, Paul. J. and Boffetta, Paolo. and Hekmatdoost, Azita and Malekzadeh, Reza and Abnet, Christian C. (2017) Toenail mineral concentration and risk of esophageal squamous cell carcinoma, results from the Golestan Cohort Study. Cancer Medicine, 6 (12). pp. 3052-3059. ISSN 20457634


Download (99kB) | Preview
Official URL:


Studies conducted in China linked selenium deficiency to higher risk of esophageal squamous cell carcinoma (ESCC), but this has not been widely tested outside that selenium-deficient region. The aim of this study was to investigate the association between selenium and other mineral concentrations in toenails and risk of ESCC in a region with high incidence rates. In this nested case-control study, we identified 222 cases of ESCC from the Golestan Cohort Study, Iran, which has followed up 50,045 participants since enrollment (2004-2008). We randomly selected one control for each case matched by age and sex, using incidence density sampling. We used toenail samples collected at baseline to measure the concentration of selenium, zinc, chromium, mercury, and scandium using instrumental neutron activation analysis. Multivariate adjusted logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals. Median nail selenium, zinc, chromium, and mercury levels were 1.01, 74.59, 0.77, and 0.018 μg/g in cases and 1.02, 75.71, 0.71, and 0.023 μg/g in controls, respectively. The adjusted odds ratios comparing each fourth quartile of mineral status versus the first quartile were as follows: selenium = 0.78 (95% CI, 0.41-1.49); zinc=0.80 (95% CI, 0.42-1.53); chromium = 0.91 (95% CI, 0.46-1.80); and mercury=0.61 (95% CI, 0.27-1.38), and all trend tests were non-significant. The nail selenium concentration in our controls reflects relatively high selenium status. No evidence of association between selenium or chromium concentrations in toenails and the risk of ESCC was detected in this population.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Saeed Shoja
Date Deposited: 27 Feb 2018 08:22
Last Modified: 27 Feb 2018 08:22

Actions (login required)

View Item View Item