Effects of Eight Week Aerobic Training on Monocytes ABCG5 Gene Expression in Middle-Aged Men after Heart Bypass Surgery

Khajei, Rambod and Haghighi, Amir Hossein and Hamedinia, Mohammad Reza and Lamir, Amir Rashid (2017) Effects of Eight Week Aerobic Training on Monocytes ABCG5 Gene Expression in Middle-Aged Men after Heart Bypass Surgery. Journal of Sabzevar University of Medical Sciences, 24 (1). pp. 79-88.

[img]
Preview
 Text
JSUMS_Volume 24_Issue 1_Pages 43-49.pdf
Download (848kB) | Preview
Official URL: http://jsums.medsab.ac.ir/article_947.html

Abstract

Background & Objectives: Cardiac rehabilitation is the most important proceeding to reduce the effects of heart surgery and its effects on cardiovascular disease. Exercise training because of low cost and being attractive can be a motivation for patients with cardiac rehabilitation programs.Exercise has influence on blood cellular components, especially the number of white blood cells, metabolism, metabolites, peptides and different type of gene expression.The aim of this study was to examine the effect of aerobic training on monocytes gene expression ABCG5 in middle-aged men after heart bypass surgery. Materials & Methods: In this semi-experimental study, 20 middle-aged malepatient who had coronary artery bypass surgery, were subjected to the study and were randomly assigned into two groups: control (N=10) and aerobic training (N = 10) groups. Blood samples were taken from subjects before and after training sessions.Monocytes isolated by centrifugation and m-RNA purified by Real-Time PCR was performed.Data were analyzed by ANOVA with repeated measures (SPSS version 16). Results: Results showed that, as a result of exercise training, there was significant increase in mRNA expression of gene ABCG5 in the experimental group than control group. Conclusion: It seems that exercise training as part of the cardiac rehabilitation in patients undergoing coronary artery bypass grafting can improve the reverse cholesterol transport process in the patients by impressing the expression of genes involved in lipid metabolism.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Saeed Shoja
Date Deposited: 19 Feb 2018 07:28
Last Modified: 19 Feb 2018 07:28
URI: http://eprints.medsab.ac.ir/id/eprint/111

Actions (login required)

View Item View Item
Medsab is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.